Quinolines and derivatives
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5000366166 NILOTINIB 200MG
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eMolecules 8-Ethoxy-5-nitroquinoline | 19746-57-7 | 1G | Purity: 98%
Combi-Blocks | 8-Ethoxy-5-nitroquinoline | 1G | 19746-57-7 | MFCD00777819
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4-(Ethoxycarbonyl)-N,N,N-trimethylbenzenaminium trifluoromethanesulfonate, 124915-06-6, 95%
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Apexbio Technology LLC ASP3026 1097917-15-1 200mg
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ASP3026 (CAS 1097917-15-1) is a selective inhibitor of anaplastic lymphoma kinase (ALK) exhibiting an IC50 of 3 5 nM for ALK enzymatic inhibition When evaluated across a panel of 86 tyrosine kinases ASP3026 demonstrated highest selectivity for ALK ROS and ACK kinases In cellular studies ASP3026 inhibited the proliferation of EML4-ALK-expressing NCI-H2228 non-small cell lung cancer (NSCLC) cells (IC50 64 8 nM) and reduced viability in NPM-ALK anaplastic large cell lymphoma (ALCL) lines with IC50 values ranging from 0 4 to 2 5 M In vivo oral administration of ASP3026 in mouse xenograft models suppressed ALK phosphorylation and significantly reduced tumor growth ASP3026 serves as a valuable tool for investigating ALK-driven oncogenesis and for preclinical evaluation of ALK-targeted therapies
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